Playing devil's advocate here, I can imagine a future with pilotless RPT.
As Nev said it's been possible for years, and the US has been flying drones over the middle East from Nevada for years too.
It's a whole lot easier than trying to make driverless road vehicles as there's not many situations in the air where you have to decide whether to hit a streetlamp or that kid chasing his ball.
The emergency situations where you need a pilot are the real issue (thinking QF2, Hudson river landing) and of course if you lost all electrical power you're stuffed. And the possibility of being hacked of course.
But on the positive side you avoid suicide by pilot (GermanWings, MH370) and some pilot error situations.
You would have to have a type qualified pilot in or near a fully connected simulator but they could possibly be backup for several flights simultaneously.
Not saying I'd be keen to board a flight without a trained human at the pointy end, but just saying it may well happen.